BLACK FUNGUS – AN EPIDEMIC

What is black fungus:-.

Black fungus targeting covid-19 patients in India:-

India has reported infections with mucormycosis, often termed “Black fungus”, in patients with covid-19 positive and recovering from coronavirus. In March 2021, 41 cases of covid-19 associated with mucormycosis had been documented around the world, with 70 per cent in India. Reports recommended the number of cases is presently a lot higher, which is evident given the current flood of covid-19 disease in India. Earlier mucormycosis was not notified like malaria, and hence its cases were not recorded and not stored in a database. Till now, there is no official figure on the total points of black fungus. The union health ministry for state and union territories to declare black fungus as an epidemic.

Specialists accept mucormycosis, which has a general death pace of half, might be being set off by using steroids, a daily existence saving treatment for extreme and fundamentally sick Covid-19 patients.

Steroids lessen aggravation in the lungs for Covid-19 and seem to help stop a portion of the harm that can happen when the body’s insusceptible framework goes into overdrive to fend off Covid. However, they additionally lessen invulnerability and push up glucose levels in the two diabetics and non-diabetic Covid-19 patients.

It’s the idea that this drop in resistance could be setting off these instances of mucormycosis.

Symptoms of mucormycosis:-

According to medical experts, the primary fungus infection refaces, which is referred to as “rhino cerebral mucormycosis”, and may even cause different facial deformities.

1) Black crust around the nose- the formation of black crust, swelling in and around the nasal passage and the eyes in a particular attribute.

2) Headache and swelling around the forehead-perhaps the most extreme confusions with black fungus happens when it spreads to the cerebrum and causes anxious aggravation. Headaches, swelling redness, pain in the forehead could be initial signs.

3) Swelling in cheeks eyes are parts of the face- pain in the cheekbone are experiencing one-sided facial pain sore short of numbness, and it may also lead to skin infections.

4) Vision loss / partial blindness- Some office may undergo symptoms like redness in the eye, eye pain, partial blindness or loss of vision.

5) Pulmonary functions-as the moulds are inhaled by the patient, the fungi can spread and grow through the respiratory passage and affect the lungs. It causes nose bleeds, nasal blockage, cough, chest pain which are some respiratory systems connected to covid-19.

Challenges in treating black fungus:-

The treatment requires multidisciplinary skill because the contagious disease spreads through the nose and eyes and can arrive at the cerebrum.

Treatment included precisely eliminating all the dead and contaminated tissue. In certain patients, this may bring about loss of the upper jaw sometimes, even the eye.

The fix may likewise include a 4-6 week course of intravenous antifungal treatment. Since it influences different parts of the body, therapy requires a group of microbiologists, inside medication specialists, intensive nervous system specialists, ENT subject matter experts, ophthalmologists, dental specialists and others.

Controlling diabetes is one of the preeminent anticipation strategies proposed by ICMR. Thus Coronavirus patients who are diabetic need to take the most extreme consideration. The prevention is checking our sugar levels on time and proper intake of food. Patients recovering from covid-19 should be tested in time to keep their right diabetic level. Doctors have to be precise with the black fungal infection treatment drugs on intravenous antifungal injection that is said to be effective in preventing the black fungus. The price of this medicine is said to be around 3500 INR. According to the data, there has been a reduction of 99 per cent of the disease in patients after introducing this drug. Self medicine and over measurements of steroids can bring about lethal occasions, and consequently, specialists’ solutions ought to be stringently followed.

Source:- The Indian express, NDTV, BBC, CNN

Written by – R Mohamed Irfan

RUSSIAN VACCINE; SPUTNIK V

       The SPUTNIK V vaccine was found by Gamaleya National research institute, Moscow, Russia. The covid-19 vaccine SPUTNIK V [ Gam-COVID-vac ] is an adenoviral-based two-part vaccine against the SARS-COV-2 coronavirus. SPUTNIK V uses weakened viruses to deliver small parts of pathogens and stimulate an immune response. It is a vector vaccine based on adenovirus DNA in which SARS – COV -2 coronavirus gene is integrated.

Third vaccine launch in INDIA; when and how much all you need to know? 

                     Deepak Sapra, the CEO of API and services at Dr. Reddy’s laboratories, which are manufacturing the Russian vaccine in India, confirmed the launch of the SPUTNIK V vaccine on Friday. It is the second most expensive vaccine to be launched in India as it has been priced at rupees 995.40, including goods and service tax. As the Russian vaccine is also to be manufactured in India, No word on pricing for the India-made shots yet, but the company aims to cut input costs as much as possible to offer it at the lowest price. A company has said the production of enough vaccines is expected to begin in mid-June. “We are pleased to announce that the first consignment of 1,50,000 doses of the Sputnik V vaccine has landed in Hyderabad from Russia,” said Dr. Reddy’s Laboratories CEO-API and Services Deepak Sapra. 

When will the SPUTNIK V be available? 

Since it has to be stored at a temperature of minus 18 degrees Celsius, the vaccine will be available in 35 cities across India. As the tests are underway for keeping the wax in between 2 to 8 degrees Celsius, and if results are favorable, a wide rollout is expected but faster. Russian Direct Investment Fund (RDIF), the Russian sovereign wealth fund that has funded the vaccine, has signed pacts with five Indian companies to produce 850 million doses. The doses will not only be made in India but also exported to third countries. Between June 2021 to March 2022, around 238 million doses will be produced in the country. India is also expected to get 11 million doses in the form of fill and finish. After getting clearance from the Drug regulator in the country, the vaccine was finally launched in the country on Friday. The first dose of the vaccine was administered to an adult in Hyderabad on Friday. 

Let’s compare; COVISHEILD, COVAXIN to SPUTNIK V

●    COVISHEILD, manufactured by the serum institute of India, costs rupees 300 per dose and rupees 600 in private hospitals. International clinical trials of COVISHEILD have shown 90 % efficiency when people are given half doors and then full dose.

● A 24-year-old vaccine maker manufactures COVAXIN with a portfolio of 16 vaccines and exports to 123 countries – BHARAT BIOTECH used a sample of coronavirus, isolated by India’s National Institute of virology. The Covaxin is priced at rupees 600 for a single dose and 1200 rupees for private hospitals. COVAXIN has 81 percentage efficiency as for the final trials.

SPUTNIK V EFFICIENCY IN INDIA 

        ACCORDING TO A PUBLICATION IN A SCIENTIFIC JOURNAL, SPUTNIK V has an efficiency of 91.6%, The Lancet. In real-world data, SPUTNIK V compares ” very very favorable” with other global vaccines and is among the top two.

Denis Logunov, deputy director of the Gamaleya research centre, said that a study has shown the SPUTNIK V vaccine is working well against new coronavirus mutations. Experts have said SPUTNIK V will be more effective in India. Yes, four deaths are reported after the vaccination trials, but the deaths are not related to the vaccination. As a total of 20000 volunteers have participated in the three trials of the SPUTNIK V vaccine, the study found no strong allergies caused by Sputnik V.

                       Sources :- NDTV , THE INDIAN EXPRESS , THE HINDU

Written by – R Mohamed Irfan